CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.310.40
Functional Family N-glycosylase/DNA lyase isoform X2

Enzyme Information

3.2.2.-
Hydrolyzing N-glycosyl compounds.
based on mapping to UniProt O15527
4.2.99.18
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt O15527
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.

UniProtKB Entries (1)

O15527
OGG1_HUMAN
Homo sapiens
N-glycosylase/DNA lyase

PDB Structure

PDB 1N39
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase
Norman, D.P., Chung, S.J., Verdine, G.L.
Biochemistry