CATH Classification

Domain Context

CATH Clusters

Superfamily RNA-directed RNA polymerase lambda-3
Functional Family

Enzyme Information

2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt P0CK31
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

P0CK31
RDRP_REOVD
Mammalian orthoreovirus 3 Dearing
RNA-directed RNA polymerase lambda-3

PDB Structure

PDB 1N1H
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
RNA Synthesis in a Cage--Structural Studies of Reovirus Polymerase [lambda] 3
Tao, Y., Farsetta, D.L., Nibert, M.L., Harrison, S.C.
Cell(Cambridge,Mass.)