CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family GDP-mannose 6-dehydrogenase

Enzyme Information

1.1.1.132
GDP-mannose 6-dehydrogenase.
based on mapping to UniProt P11759
GDP-D-mannose + 2 NAD(+) + H(2)O = GDP-D-mannuronate + 2 NADH.
-!- Also uses the corresponding deoxynucleoside diphosphate derivative as a substrate.

UniProtKB Entries (1)

P11759
ALGD_PSEAE
Pseudomonas aeruginosa PAO1
GDP-mannose 6-dehydrogenase

PDB Structure

PDB 1MV8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of GDP-mannose dehydrogenase: A key enzyme in alginate biosynthesis of P. aeruginosa
Snook, C.F., Tipton, P.A., Beamer, L.J.
Biochemistry