1 keywords

CATH Domain 1ms6A00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.70 Cathepsin B; Chain A
Homologous Superfamily 3.90.70.10 Cysteine proteinases

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.27
Cathepsin S.
based on mapping to UniProt P25774
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25774
CATS_HUMAN
Homo sapiens
Cathepsin S

PDB Structure

PDB 1MS6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors
Ward, Y.D., Thomson, D.S., Frye, L.L., Cywin, C.L., Morwick, T., Emmanuel, M.J., Zindell, R., McNeil, D., Bekkali, Y., Giradot, M., Hrapchak, M., DeTuri, M., Crane, K., White, D., Pav, S., Wang, Y., Hao, M.H., Grygon, C.A., Labadia, M.E., Freeman, D.M., Davidson, W., Hopkins, J.L., Brown, M.L., Spero, D.M.
J.Med.Chem.