CATH Classification

Domain Context

CATH Clusters

Superfamily Methyl-coenzyme M reductase, gamma subunit
Functional Family

Enzyme Information

2.8.4.1
Coenzyme-B sulfoethylthiotransferase.
based on mapping to UniProt P11562
Methyl-CoM + CoB = CoM-S-S-CoB + methane.
-!- This enzyme catalyzes the final step in methanogenesis, the biological production of methane. -!- This important anaerobic process is carried out only by methanogenic archaea. -!- The enzyme can also function in reverse, for anaerobic oxidation of methane. -!- The enzyme requires the hydroporphinoid nickel complex coenzyme F(430). -!- Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. -!- The sulfide sulfur can be replaced by selenium but not by oxygen.

UniProtKB Entries (1)

P11562
MCRG_METTM
Methanothermobacter marburgensis str. Marburg
Methyl-coenzyme M reductase I subunit gamma

PDB Structure

PDB 1MRO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
Ermler, U., Grabarse, W., Shima, S., Goubeaud, M., Thauer, R.K.
Science