CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose-6-phosphate isomerase like protein; domain 1
Functional Family Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Enzyme Information

2.6.1.16
Glutamine--fructose-6-phosphate transaminase (isomerizing).
based on mapping to UniProt P17169
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
-!- Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination). -!- Formerly EC 5.3.1.19.

UniProtKB Entries (1)

P17169
GLMS_ECOLI
Escherichia coli K-12
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

PDB Structure

PDB 1MOQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain.
Teplyakov, A., Obmolova, G., Badet-Denisot, M.A., Badet, B., Polikarpov, I.
Structure