CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glyceraldehyde-3-phosphate dehydrogenase

Enzyme Information

1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
based on mapping to UniProt P22513
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
-!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate.

UniProtKB Entries (1)

P22513
G3PG_TRYCR
Trypanosoma cruzi
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

PDB Structure

PDB 1ML3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Evidence for the Two Phosphate Binding Sites of an Analogue of the Thioacyl Intermediate for the Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase-Catalyzed Reaction, from Its Crystal Structure.
Castilho, M.S., Pavao, F., Oliva, G., Ladame, S., Willson, M., Perie, J.
Biochemistry