CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.140 | Spermidine Synthase; Chain: A, domain 2 |
|
2.30.140.10 | Spermidine synthase, tetramerisation domain |
Domain Context
CATH Clusters
| Superfamily | Spermidine synthase, tetramerisation domain |
| Functional Family | Polyamine aminopropyltransferase |
Enzyme Information
| 2.5.1.104 |
N(1)-aminopropylagmatine synthase.
based on mapping to UniProt Q8U4G1
S-adenosylmethioninamine + agmatine = S-methyl-5'-thioadenosine + N(1)- (3-aminopropyl)agmatine.
-!- The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria. -!- The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency. -!- The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency. -!- Cf. EC 2.5.1.16 and EC 2.5.1.23.
|
| 2.5.1.- |
Transferring alkyl or aryl groups, other than methyl groups.
based on mapping to UniProt Q8U4G1
|
| 2.5.1.16 |
Spermidine synthase.
based on mapping to UniProt Q8U4G1
S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine.
-!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.
|
| 2.5.1.23 |
Sym-norspermidine synthase.
based on mapping to UniProt Q8U4G1
S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine = S-methyl- 5'-thioadenosine + bis(3-aminopropyl)amine.
-!- The enzyme has been originally characterized from the protist Euglena gracilis. -!- The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency. -!- Cf. EC 2.5.1.16 and EC 2.5.1.22.
|
UniProtKB Entries (1)
| Q8U4G1 |
SPEE_PYRFU
Pyrococcus furiosus DSM 3638
Polyamine aminopropyltransferase
|
PDB Structure
| PDB | 1MJF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
PUTATIVE SPERMIDINE SYNTHETASE FROM PYROCOCCUS FURIOSUS PFU-132382
to be published
|