CATH Classification

Domain Context

CATH Clusters

Superfamily Golgi alpha-mannosidase II
Functional Family Pancreatic alpha-amylase

Enzyme Information

3.2.1.1
Alpha-amylase.
based on mapping to UniProt P04745
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
-!- Acts on starch, glycogen and related polysaccharides and oligosaccharides in a random manner; reducing groups are liberated in the alpha-configuration. -!- The term 'alpha' relates to the initial anomeric configuration of the free sugar group released and not to the configuration of the linkage hydrolyzed.

UniProtKB Entries (1)

P04745
AMY1_HUMAN
Homo sapiens
Alpha-amylase 1

PDB Structure

PDB 1MFU
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase.
Ramasubbu, N., Ragunath, C., Mishra, P.J.
J.Mol.Biol.