CATH Classification

Domain Context

CATH Clusters

Superfamily Macrophage Migration Inhibitory Factor
Functional Family Macrophage migration inhibitory factor

Enzyme Information

5.3.2.1
Phenylpyruvate tautomerase.
based on mapping to UniProt P34884
Keto-phenylpyruvate = enol-phenylpyruvate.
-!- Also acts on other arylpyruvates.
5.3.3.12
L-dopachrome isomerase.
based on mapping to UniProt P34884
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
-!- Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate). -!- Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).

UniProtKB Entries (1)

P34884
MIF_MOUSE
Mus musculus
Macrophage migration inhibitory factor

PDB Structure

PDB 1MFI
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.
Taylor, A.B., Johnson Jr., W.H., Czerwinski, R.M., Li, H.S., Hackert, M.L., Whitman, C.P.
Biochemistry