CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family

Enzyme Information

6.3.3.4
(Carboxyethyl)arginine beta-lactam-synthase.
based on mapping to UniProt P0DJQ7
ATP + L-N(2)-(2-carboxyethyl)arginine = AMP + diphosphate + deoxyamidinoproclavaminate.
-!- Forms part of the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. -!- It has been proposed that L-N(2)-(2-carboxyethyl)arginine is first converted into an acyl-AMP by reaction with ATP and loss of diphosphate, and that the beta-lactam ring is then formed by the intramolecular attack of the beta-nitrogen on the activated carboxy group.

UniProtKB Entries (1)

P0DJQ7
BLS_STRCL
Streptomyces clavuligerus
Carboxyethyl-arginine beta-lactam-synthase

PDB Structure

PDB 1MB9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Miller, M.T., Bachmann, B.O., Townsend, C.A., Rosenzweig, A.C.
Proc.Natl.Acad.Sci.USA