CATH Classification

Domain Context

CATH Clusters

Superfamily Putative methyltransferase TM0872, insert domain
Functional Family

Enzyme Information

2.1.1.199
16S rRNA (cytosine(1402)-N(4))-methyltransferase.
based on mapping to UniProt Q9WZX6
S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.
-!- RsmH catalyzes the N(4)-methylation of cytosine(1402) and RsmI (EC 2.1.1.198) catalyzes the 2'-O-methylation of cytosine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

UniProtKB Entries (1)

Q9WZX6
RSMH_THEMA
Thermotoga maritima MSB8
Ribosomal RNA small subunit methyltransferase H

PDB Structure

PDB 1M6Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain
Miller, D.J., Ouellette, N., Evdokimova, E., Savchenko, A., Edwards, A., Anderson, W.F.
Protein Sci.