CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P0ABZ6
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P0ABZ6
SURA_ECOLI
Escherichia coli K-12
Chaperone SurA

PDB Structure

PDB 1M5Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystallographic Structure of SurA, a Molecular Chaperone that Facilitates Folding of Outer Membrane Porins
Bitto, E., McKay, D.B.
Structure