CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family Histo-blood group ABO system transferase

Enzyme Information

2.4.1.37
Fucosylgalactoside 3-alpha-galactosyltransferase.
based on mapping to UniProt P16442
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.
-!- Acts on blood group substance, and can use a number of 2-fucosyl- galactosides as acceptors.
2.4.1.40
Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase.
based on mapping to UniProt P16442
UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl- (1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl- (1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.
-!- Acts on blood group substance H. -!- Can use a number of 2-fucosyl-galactosides as acceptors.

UniProtKB Entries (1)

P16442
BGAT_HUMAN
Homo sapiens
Histo-blood group ABO system transferase

PDB Structure

PDB 1LZ0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structural basis for specificity in human ABO(H) blood group biosynthesis.
Patenaude, S.I., Seto, N.O., Borisova, S.N., Szpacenko, A., Marcus, S.L., Palcic, M.M., Evans, S.V.
Nat.Struct.Biol.