CATH Classification

Domain Context

CATH Clusters

Superfamily Polysaccharide lyase family 8-like, C-terminal
Functional Family

Enzyme Information

4.2.2.1
Hyaluronate lyase.
based on mapping to UniProt Q53591
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.
-!- The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction. -!- Also acts on chondroitin. -!- The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. -!- Formerly EC 4.2.99.1.

UniProtKB Entries (1)

Q53591
HYSA_STRA3
Streptococcus agalactiae NEM316
Hyaluronate lyase

PDB Structure

PDB 1LXM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan.
Mello, L.V., De Groot, B.L., Li, S., Jedrzejas, M.J.
J.Biol.Chem.