CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.10
Functional Family Chitinase 3-like 1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt Q13231
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

Q13231
CHIT1_HUMAN
Homo sapiens
Chitotriosidase-1

PDB Structure

PDB 1LQ0
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins
Fusetti, F., Von Moeller, H., Houston, D., Rozeboom, H.J., Dijkstra, B.W., Boot, R.G., Aerts, J.M., Van Aalten, D.M.
J.Biol.Chem.