CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Functional Family Glutamate synthase, large subunit

Enzyme Information

1.4.7.1
Glutamate synthase (ferredoxin).
based on mapping to UniProt P55038
2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H(+).
-!- The protein is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate. -!- The NH(3) is channeled through a 24 A channel in the active protein. -!- No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein.

UniProtKB Entries (1)

P55038
GLTS_SYNY3
Synechocystis sp. PCC 6803 substr. Kazusa
Ferredoxin-dependent glutamate synthase 2

PDB Structure

PDB 1LLW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural studies on the synchronization of catalytic centers in glutamate synthase
van den Heuvel, R.H., Ferrari, D., Bossi, R.T., Ravasio, S., Curti, B., Vanoni, M.A., Florencio, F.J., Mattevi, A.
J.BIOL.CHEM.