CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Transcriptional repressor, LexA family

Enzyme Information

3.4.21.88
Repressor LexA.
based on mapping to UniProt P0A7C2
Hydrolysis of Ala-|-Gly bond in repressor LexA.
-!- In the presence of single-stranded DNA, the RecA protein interacts with LexA causing an autocatalytic cleavage which disrupts the DNA- binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. -!- The activity was previously attributed to the RecA protein (formerly EC 3.4.99.37). -!- Belongs to peptidase family S24.

UniProtKB Entries (1)

P0A7C2
LEXA_ECOLI
Escherichia coli K-12
LexA repressor

PDB Structure

PDB 1LEB
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of the LexA repressor DNA binding domain determined by 1H NMR spectroscopy.
Fogh, R.H., Ottleben, G., Ruterjans, H., Schnarr, M., Boelens, R., Kaptein, R.
EMBO J.