CATH Classification

Domain Context

CATH Clusters

Superfamily Transglutaminase-like
Functional Family Protein-glutamine gamma-glutamyltransferase 2

Enzyme Information

2.3.2.13
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt Q08188
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

Q08188
TGM3_HUMAN
Homo sapiens
Protein-glutamine gamma-glutamyltransferase E

PDB Structure

PDB 1L9N
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation.
Ahvazi, B., Kim, H.C., Kee, S.H., Nemes, Z., Steinert, P.M.
EMBO J.