CATH Classification

Domain Context

CATH Clusters

Superfamily Aconitate B, HEAT-like domain
Functional Family Aconitate hydratase B

Enzyme Information

4.2.1.99
2-methylisocitrate dehydratase.
based on mapping to UniProt P36683
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3- tricarboxylate + H(2)O.
-!- The enzyme from the fungus Yarrowia lipolytica does not act on isocitrate.
4.2.1.3
Aconitate hydratase.
based on mapping to UniProt P36683
Citrate = isocitrate.
-!- Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate. -!- The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate. -!- Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate. -!- Formerly EC 4.2.1.4.

UniProtKB Entries (1)

P36683
ACNB_ECOLI
Escherichia coli K-12
Aconitate hydratase B

PDB Structure

PDB 1L5J
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition.
Williams, C.H., Stillman, T.J., Barynin, V.V., Sedelnikova, S.E., Tang, Y., Green, J., Guest, J.R., Artymiuk, P.J.
Nat.Struct.Biol.