CATH Classification

Domain Context

CATH Clusters

Superfamily Taq DNA Polymerase; Chain T, domain 4
Functional Family DNA polymerase I, thermostable

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P52026
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P52026
DPO1_GEOSE
Geobacillus stearothermophilus
DNA polymerase I

PDB Structure

PDB 1L3U
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
Johnson, S.J., Taylor, J.S., Beese, L.S.
Proc.Natl.Acad.Sci.USA