CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Adenosylhomocysteinase

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt P10760
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P10760
SAHH_RAT
Rattus norvegicus
Adenosylhomocysteinase

PDB Structure

PDB 1KY5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Catalytic Mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
Takata, Y., Yamada, T., Huang, Y., Komoto, J., Gomi, T., Ogawa, H., Fujioka, M., Takusagawa, F.
J.Biol.Chem.