CATH Classification

Domain Context

CATH Clusters

Superfamily Quinoprotein alcohol dehydrogenase-like superfamily
Functional Family Methanol dehydrogenase, large subunit

Enzyme Information

1.1.9.1
Alcohol dehydrogenase (azurin).
based on mapping to UniProt Q8GR64
A primary alcohol + azurin = an aldehyde + reduced azurin.
-!- Occurs in Comamonas and Pseudomonas. -!- Does not require an amine activator. -!- Oxidizes a wide range of primary and secondary alcohols, and also aldehydes and large substrates such as sterols; methanol is not a substrate. -!- Usually assayed with phenazine methosulfate or ferricyanide. -!- Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ. -!- Formerly EC 1.1.98.1.

UniProtKB Entries (1)

Q8GR64
QHED_PSEPU
Pseudomonas putida
Quinohemoprotein alcohol dehydrogenase ADH IIB

PDB Structure

PDB 1KV9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure at 1.9 A resolution of a quinohemoprotein alcohol dehydrogenase from Pseudomonas putida HK5.
Chen, Z.W., Matsushita, K., Yamashita, T., Fujii, T.A., Toyama, H., Adachi, O., Bellamy, H.D., Mathews, F.S.
Structure