CATH Classification

Domain Context

CATH Clusters

Superfamily Taq DNA Polymerase; Chain T, domain 4
Functional Family DNA polymerase I

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P00582
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

P00582
DPO1_ECOLI
Escherichia coli K-12
DNA polymerase I

PDB Structure

PDB 1KRP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.
Brautigam, C.A., Steitz, T.A.
J.Mol.Biol.