CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00374
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00374
DYR_HUMAN
Homo sapiens
Dihydrofolate reductase

PDB Structure

PDB 1KMS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.
Klon, A.E., Heroux, A., Ross, L.J., Pathak, V., Johnson, C.A., Piper, J.R., Borhani, D.W.
J.Mol.Biol.