CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Functional Family Succinate dehydrogenase flavoprotein subunit (SdhA)

Enzyme Information

1.3.5.4
Fumarate reductase (quinol).
based on mapping to UniProt P00363
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P00363
FRDA_ECOLI
Escherichia coli K-12
Fumarate reductase flavoprotein subunit

PDB Structure

PDB 1KF6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site.
Iverson, T.M., Luna-Chavez, C., Croal, L.R., Cecchini, G., Rees, D.C.
J.Biol.Chem.