CATH Classification

Domain Context

CATH Clusters

Superfamily UDP-galactose 4-epimerase, domain 1
Functional Family dTDP-4-dehydrorhamnose reductase

Enzyme Information

1.1.1.133
dTDP-4-dehydrorhamnose reductase.
based on mapping to UniProt P26392
dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH.
-!- In the reverse direction, reduction on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyzes epimerization at C-3 and C-5; the complex has been referred to as dTDP-L-rhamnose synthase.

UniProtKB Entries (1)

P26392
RMLD_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
DTDP-4-dehydrorhamnose reductase

PDB Structure

PDB 1KBZ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode.
Blankenfeldt, W., Kerr, I.D., Giraud, M.F., McMiken, H.J., Leonard, G., Whitfield, C., Messner, P., Graninger, M., Naismith, J.H.
Structure