CATH Domain 1k4vA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
	3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family	Histo-blood group ABO system transferase

Enzyme Information

2.4.1.87

N-acetyllactosaminide 3-alpha-galactosyltransferase.

based on mapping to UniProt P14769

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D- glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl- (1->4)-beta-N-acetylglucosaminyl-R.

-!- Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo- alpha(1)-acid glycoprotein and N-acetyllactosamine (beta-D- galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. -!- The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. -!- Formerly EC 2.4.1.124 and EC 2.4.1.151.

UniProtKB Entries (1)

P14769

GGTA1_BOVIN

Bos taurus

N-acetyllactosaminide alpha-1,3-galactosyltransferase

PDB Structure

PDB	1K4V
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure of UDP complex of UDP-galactose:beta-galactoside-alpha -1,3-galactosyltransferase at 1.53-A resolution reveals a conformational change in the catalytically important C terminus. Boix, E., Swaminathan, G.J., Zhang, Y., Natesh, R., Brew, K., Acharya, K.R. J.Biol.Chem.