CATH Classification

Domain Context

CATH Clusters

Superfamily Cathepsin C, exclusion domain
Functional Family Dipeptidyl peptidase 1

Enzyme Information

3.4.14.1
Dipeptidyl-peptidase I.
based on mapping to UniProt P53634
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.
-!- Also polymerizes dipeptide amides, arylamides and esters at neutral pH. -!- Cl(-)-dependent lysosomal cysteine-type peptidase. -!- Belongs to peptidase family C1. -!- Formerly EC 3.4.4.9.

UniProtKB Entries (1)

P53634
CATC_HUMAN
Homo sapiens
Dipeptidyl peptidase 1

PDB Structure

PDB 1K3B
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases.
Turk, D., Janjic, V., Stern, I., Podobnik, M., Lamba, D., Dahl, S.W., Lauritzen, C., Pedersen, J., Turk, V., Turk, B.
EMBO J.