CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P42679
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P42679
MATK_HUMAN
Homo sapiens
Megakaryocyte-associated tyrosine-protein kinase

PDB Structure

PDB 1JWO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase
Murthy, T.V.S., Webster, G.D.
To be Published