CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Adenylyltransferase and sulfurtransferase MOCS3

Enzyme Information

2.7.7.80
Molybdopterin-synthase adenylyltransferase.
based on mapping to UniProt P12282
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly- Gly-AMP.
-!- Adenylates the C-terminus of the small subunit of the molybdopterin synthase. -!- This activation is required to form the thiocarboxylated C-terminus of the active molybdopterin synthase small subunit. -!- The reaction occurs in prokaryotes and eukaryotes. -!- In the human, the reaction is catalyzed by the N-terminal domain of the protein MOCS3, which also includes a molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) C-terminal domain. -!- Formerly EC 2.7.7.n4.

UniProtKB Entries (1)

P12282
MOEB_ECOLI
Escherichia coli K-12
Molybdopterin-synthase adenylyltransferase

PDB Structure

PDB 1JWA
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.
Lake, M.W., Wuebbens, M.M., Rajagopalan, K.V., Schindelin, H.
Nature