CATH Classification

Domain Context

CATH Clusters

Superfamily 2.30.120.10
Functional Family

Enzyme Information

3.5.1.93
Glutaryl-7-aminocephalosporanic-acid acylase.
based on mapping to UniProt Q9L5D6
(7R)-7-(4-carboxybutanamido)cephalosporanate + H(2)O = (7R)-7- aminocephalosporanate + glutarate.
-!- Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. -!- It reacts only weakly with cephalosporin C.

UniProtKB Entries (1)

Q9L5D6
G7AC_BREDI
Brevundimonas diminuta
Glutaryl-7-aminocephalosporanic-acid acylase

PDB Structure

PDB 1JW0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of cephalosporin acylase in complex with glutaryl-7-aminocephalosporanic acid and glutarate: insight into the basis of its substrate specificity
Kim, Y., Hol, W.G.
CHEM.BIOL.