CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.572 | Thymidylate Synthase; Chain A |
|
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
| Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
| Functional Family | Thymidylate synthase |
Enzyme Information
| 2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P0A884
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
| P0A884 |
TYSY_ECOLI
Escherichia coli K-12
Thymidylate synthase
|
PDB Structure
| PDB | 1JUT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
J.Mol.Biol.
|