CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P20248
CCNA2_HUMAN
Homo sapiens
Cyclin-A2

PDB Structure

PDB 1JST
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural basis of cyclin-dependent kinase activation by phosphorylation.
Russo, A.A., Jeffrey, P.D., Pavletich, N.P.
Nat.Struct.Biol.