CATH Classification

Domain Context

CATH Clusters

Superfamily Butyryl-CoA Dehydrogenase, subunit A, domain 3
Functional Family Acyl-CoA dehydrogenase FadE25

Enzyme Information
Short-chain acyl-CoA dehydrogenase.
based on mapping to UniProt P15651
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
-!- One of several enzymes that catalyze the first step in fatty acids beta-oxidation. -!- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R hydrogen atoms. -!- The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. -!- The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA. -!- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA. -!- Cf. EC, EC and EC -!- Formerly EC and EC

UniProtKB Entries (1)

Rattus norvegicus
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

PDB Structure

External Links
Organism Escherichia
Primary Citation
Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.
Battaile, K.P., Molin-Case, J., Paschke, R., Wang, M., Bennett, D., Vockley, J., Kim, J.J.