CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Carboxylic ester hydrolase

Enzyme Information

3.1.1.13
Sterol esterase.
based on mapping to UniProt P19835
A steryl ester + H(2)O = a sterol + a fatty acid.
-!- A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. -!- Activated by bile salts.
3.1.1.3
Triacylglycerol lipase.
based on mapping to UniProt P19835
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
-!- The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.

UniProtKB Entries (1)

P19835
CEL_HUMAN
Homo sapiens
Bile salt-activated lipase

PDB Structure

PDB 1JMY
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding.
Moore, S.A., Kingston, R.L., Loomes, K.M., Hernell, O., Blackberg, L., Baker, H.M., Baker, E.N.
J.Mol.Biol.