CATH Classification

Domain Context

CATH Clusters

Superfamily MoaB/Mog-like domain
Functional Family Molybdopterin molybdenumtransferase

Enzyme Information

2.10.1.1
Molybdopterin molybdotransferase.
based on mapping to UniProt Q9NQX3
Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.
-!- Catalyzes the insertion of molybdenum into the ene-dithiol group of molybdopterin. -!- In eukaryotes this reaction is catalyzed by the N-terminal domain of a fusion protein whose C-terminal domain catalyzes EC 2.7.7.75.
2.7.7.75
Molybdopterin adenylyltransferase.
based on mapping to UniProt Q9NQX3
ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
-!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes molybdopterin molybdotransferase (EC 2.10.1.1). -!- The reaction requires a divalent cation such as Mg(2+) or Mn(2+). -!- Catalyzes the activation of molybdopterin for molybdenum insertion. -!- In eukaryotes, this reaction is catalyzed by the C-terminal domain of a fusion protein that also includes EC 2.10.1.1. -!- Formerly EC 2.7.7.n5.

UniProtKB Entries (1)

Q9NQX3
GEPH_HUMAN
Homo sapiens
Gephyrin

PDB Structure

PDB 1JLJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of human gephyrin and plant Cnx1 G domains: comparative analysis and functional implications.
Schwarz, G., Schrader, N., Mendel, R.R., Hecht, H.J., Schindelin, H.
J.Mol.Biol.