CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt Q79MP6
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

Q79MP6
Q79MP6_PSEAI
Pseudomonas aeruginosa
Beta-lactamase

PDB Structure

PDB 1JJT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-beta-lactamase.
Toney, J.H., Hammond, G.G., Fitzgerald, P.M., Sharma, N., Balkovec, J.M., Rouen, G.P., Olson, S.H., Hammond, M.L., Greenlee, M.L., Gao, Y.D.
J.Biol.Chem.