CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cytochrome P450 monooxygenase |
Enzyme Information
| 1.14.15.35 |
6-deoxyerythronolide B hydroxylase.
based on mapping to UniProt Q00441
6-deoxyerythronolide B + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = erythronolide B + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O.
-!- A cytochrome P450 (heme-thiolate) protein isolated from the bacterium Saccharopolyspora erythraea. -!- The enzyme is involved in the biosynthesis of the antibiotic erythromycin. -!- Formerly EC 1.14.13.188.
|
UniProtKB Entries (1)
| Q00441 |
CPXJ_SACEN
Saccharopolyspora erythraea NRRL 2338
6-deoxyerythronolide B hydroxylase
|
PDB Structure
| PDB | 1JIP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF.
J.Mol.Biol.
|