CATH Domain 1jiiA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.240	Tyrosyl-Transfer RNA Synthetase
	1.10.240.10	Tyrosyl-Transfer RNA Synthetase

Domain Context

CATH Clusters

Superfamily	Tyrosyl-Transfer RNA Synthetase
Functional Family	Tyrosine--tRNA ligase

Enzyme Information

6.1.1.1

Tyrosine--tRNA ligase.

based on mapping to UniProt A6QHR2

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

UniProtKB Entries (1)

SYY_STAAE

Staphylococcus aureus subsp. aureus str. Newman

Tyrosine--tRNA ligase

PDB Structure

PDB	1JII
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Qiu, X., Janson, C.A., Smith, W.W., Green, S.M., McDevitt, P., Johanson, K., Carter, P., Hibbs, M., Lewis, C., Chalker, A., Fosberry, A., Lalonde, J., Berge, J., Brown, P., Houge-Frydrych, C.S., Jarvest, R.L. Protein Sci.