CATH Classification

Domain Context

CATH Clusters

Superfamily Tyrosyl-Transfer RNA Synthetase
Functional Family Tyrosine--tRNA ligase

Enzyme Information

6.1.1.1
Tyrosine--tRNA ligase.
based on mapping to UniProt A6QHR2
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).

UniProtKB Entries (1)

A6QHR2
SYY_STAAE
Staphylococcus aureus subsp. aureus str. Newman
Tyrosine--tRNA ligase

PDB Structure

PDB 1JII
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.
Qiu, X., Janson, C.A., Smith, W.W., Green, S.M., McDevitt, P., Johanson, K., Carter, P., Hibbs, M., Lewis, C., Chalker, A., Fosberry, A., Lalonde, J., Berge, J., Brown, P., Houge-Frydrych, C.S., Jarvest, R.L.
Protein Sci.