CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1100
Functional Family

Enzyme Information

4.2.1.22
Cystathionine beta-synthase.
based on mapping to UniProt P35520
L-serine + L-homocysteine = L-cystathionine + H(2)O.
-!- A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans. -!- Formerly EC 4.2.1.21.

UniProtKB Entries (1)

P35520
CBS_HUMAN
Homo sapiens
Cystathionine beta-synthase

PDB Structure

PDB 1JBQ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein.
Meier, M., Janosik, M., Kery, V., Kraus, J.P., Burkhard, P.
EMBO J.