CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.5.1.40
8-hydroxy-5-deazaflavin:NADPH oxidoreductase.
based on mapping to UniProt O29370
Reduced coenzyme F420 + NADP(+) = oxidized coenzyme F420 + NADPH.
-!- The enzyme has an absolute requirement for both the 5-deazaflavin structure and the presence of an 8-hydroxy group in the substrate.

UniProtKB Entries (1)

O29370
FNO_ARCFU
Archaeoglobus fulgidus DSM 4304
F420-dependent NADP reductase

PDB Structure

PDB 1JAY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of F420H2:NADP+ oxidoreductase with and without its substrates bound.
Warkentin, E., Mamat, B., Sordel-Klippert, M., Wicke, M., Thauer, R.K., Iwata, M., Iwata, S., Ermler, U., Shima, S.
EMBO J.