CATH Classification

Domain Context

CATH Clusters

Superfamily S-ribosylhomocysteinase (LuxS)
Functional Family

Enzyme Information

4.4.1.21
S-ribosylhomocysteine lyase.
based on mapping to UniProt P44007
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5- dihydroxypentan-2,3-dione.
-!- The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. -!- Formerly EC 3.2.1.148 and EC 3.3.1.3.

UniProtKB Entries (1)

P44007
LUXS_HAEIN
Haemophilus influenzae Rd KW20
S-ribosylhomocysteine lyase

PDB Structure

PDB 1J6W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs.
Lewis, H.A., Furlong, E.B., Laubert, B., Eroshkina, G.A., Batiyenko, Y., Adams, J.M., Bergseid, M.G., Marsh, C.D., Peat, T.S., Sanderson, W.E., Sauder, J.M., Buchanan, S.G.
Structure