CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Glycogen synthase kinase-3 beta

Enzyme Information
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P49841
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC and EC
[Tau protein] kinase.
based on mapping to UniProt P49841
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Glycogen synthase kinase-3 beta

PDB Structure

External Links
Organism Escherichia
Primary Citation
Structural insight into nucleotide recognition in tau-protein kinase I/glycogen synthase kinase 3 beta.
Aoki, M., Yokota, T., Sugiura, I., Sasaki, C., Hasegawa, T., Okumura, C., Ishiguro, K., Kohno, T., Sugio, S., Matsuzaki, T.
Acta Crystallogr.,Sect.D