CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt Q8RQP5
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q8RQP5
ISPF_THET8
Thermus thermophilus HB8
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PDB Structure

PDB 1IV1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.
Kishida, H., Wada, T., Unzai, S., Kuzuyama, T., Takagi, M., Terada, T., Shirouzu, M., Yokoyama, S., Tame, J.R., Park, S.Y.
Acta Crystallogr.,Sect.D