CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family p-hydroxybenzoate hydroxylase

Enzyme Information

1.14.13.2
4-hydroxybenzoate 3-monooxygenase.
based on mapping to UniProt P20586
4-hydroxybenzoate + NADPH + O(2) = protocatechuate + NADP(+) + H(2)O.
-!- Most enzymes from Pseudomonas are highly specific for NAD(P)H (cf. EC 1.14.13.33).

UniProtKB Entries (1)

P20586
PHHY_PSEAE
Pseudomonas aeruginosa PAO1
P-hydroxybenzoate hydroxylase

PDB Structure

PDB 1IUU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
pH-dependent structural changes in the active site of p-hydroxybenzoate hydroxylase point to the importance of proton and water movements during catalysis.
Gatti, D.L., Entsch, B., Ballou, D.P., Ludwig, M.L.
Biochemistry