CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family Isocitrate dehydrogenase [NADP]

Enzyme Information

1.1.1.42
Isocitrate dehydrogenase (NADP(+)).
based on mapping to UniProt P08200
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.

UniProtKB Entries (1)

P08200
IDH_ECOLI
Escherichia coli K-12
Isocitrate dehydrogenase [NADP]

PDB Structure

PDB 1ISO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Determinants of cofactor specificity in isocitrate dehydrogenase: structure of an engineered NADP+ --> NAD+ specificity-reversal mutant.
Hurley, J.H., Chen, R., Dean, A.M.
Biochemistry