CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family Glycosyltransferase GtfE

Enzyme Information

2.4.1.310
Vancomycin aglycone glucosyltransferase.
based on mapping to UniProt P96559
UDP-alpha-D-glucose + vancomycin aglycone = UDP + devancoaminyl- vancomycin.
-!- The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of the glycopeptide antibiotic chloroeremomycin.

UniProtKB Entries (1)

P96559
GTFB_AMYOR
Amycolatopsis orientalis
Vancomycin aglycone glucosyltransferase

PDB Structure

PDB 1IIR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.
Mulichak, A.M., Losey, H.C., Walsh, C.T., Garavito, R.M.
Structure