CATH Classification

CATH Clusters

Superfamily 1.25.40.10
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P26882
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P26882
PPID_BOVIN
Bos taurus
Peptidyl-prolyl cis-trans isomerase D

PDB Structure

PDB 1IHG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Two structures of cyclophilin 40: folding and fidelity in the TPR domains.
Taylor, P., Dornan, J., Carrello, A., Minchin, R.F., Ratajczak, T., Walkinshaw, M.D.
Structure