CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose permease domain IIB
Functional Family PTS system glucose-specific IIBC component PtsG

Enzyme Information
Protein-N(pi)-phosphohistidine--D-glucose phosphotransferase.
based on mapping to UniProt P69786
[Protein]-N(pi)-phospho-L-histidine + D-glucose(Side 1) = [protein]-L- histidine + D-glucose 6-phosphate(Side 2).
-!- This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). -!- The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. -!- The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC -!- Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. -!- The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate. -!- Formerly EC

UniProtKB Entries (1)

Escherichia coli K-12
PTS system glucose-specific EIICB component

PDB Structure

External Links
Organism Escherichia
Primary Citation
Solution structure of the IIB domain of the glucose transporter of Escherichia coli.
Eberstadt, M., Grdadolnik, S.G., Gemmecker, G., Kessler, H., Buhr, A., Erni, B.